ECTOPIC HORMONE-PRODUCING TUMORS

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Ectopic hormone production by malignant tumors.

Malignant tumours of nonendocrine tissues may produce ectopic hormones. The most likely mechanism is depression of genes which code for hormones. Ectopic hormones are invariably peptides, and each is identical to some peptide product of an endocrine gland. However, the majority of ectopic hormones occur as biologically inactive precursors or subunits and therefore remain occult unless they are ...

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With the report of the production of ACTH by non-endocrine neoplastic tissue, Meador and associates set the stage for increasing clinical awareness of ectopic hormone production from a variety of neoplasms, bronchial adenomas and oat cell carcinoma of the lung in particular. The clinical syndromes are those expected from excess secretion of ACTH, ADH, parathyroid hormone, growth hormone, insuli...

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ژورنال

عنوان ژورنال: Nihon Naika Gakkai Zasshi

سال: 1981

ISSN: 0021-5384,1883-2083

DOI: 10.2169/naika.70.821